Have I just killed my new 1080 Ti (M.2 connector)?

Did you use the GRUB_CMDLINE_LINUX_DEFAULT="quiet splash pci=nomsi" command? I think that just suppresses any PCI-related error messages… But if it’s made the card work then all good!

Further down that thread there are two other suggestions:

Disable PCI Active State Power Management in your BIOS. Could be called ASPM or PEG-ASPM. Should be easy to test.

Or if you’re more daring try updating your kernel http://www.omgubuntu.co.uk/2017/02/ukuu-easy-way-to-install-mainline-kernel-ubuntu)

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