I recommend that you wipe the system clean and install W10 afresh. If your MB has a video out connection, boot from that first. Once you’re up, add one GPU at a time, confirm it is installed and repeat. It takes time…and you need to wait for it.
You can try to adjust your virtual mem to 16gm, too in windows, but I run multiple 6 gpu miners and if one acts flaky, I reinstall windows 10 and let it go at that.